Surra.                                     23

not broken up in the mouth and that the drug is well mixed
with the other ingredients.

Throughout the treatment and for some weeks following,
the animal should receive a liberal diet and be protected
from extremes of temperature or any lowering condition.

(iii) FURTHER EXPERIMENTS ON THE TREATMENT
  OF SURRA WITH ATOXYL AND ORPIMENT AND
            OTHER PREPARATIONS OF ARSENIC.

THE object of these experiments was to confirm the
results of atoxyl and orpiment treatment published in a
previous paper* and to test the effect of this treatment when
commenced at an advanced stage of the disease.

In the case of some rabbits and guinea-pigs the treatment
was commenced about three weeks after the Surra inoculation
and two weeks after the appearance of trypanosomes in the
blood.

Unfortunately, it was not possible to adopt the same
course with the ponies. The only animals obtainable at the
time for experiment were worn out and half starved village
ponies which had no power of resistance to the disease and.
succumbed in a very short period. With these animals the
treatment was commenced, one to three and four days after
the trypanosomes were observed in the blood.

EXPERIMENTS WITH GUINEA-PIGS AND RABBITS.

Seven guinea-pigs and two rabbits received the atoxyl
and orpiment treatment and were kept under observation
for three months. In no instance did the trypanosomes re-
appear in the blood after the first injection of atoxyl. Four
of the guinea-pigs died during the period of observation.
These deaths were due to exposure to cold at night time and
to improper feeding. In the case of guinea-pig No. 287 seven
doses, in No. 288 six doses and in No. 289 four doses were
sufficient.

               EXPERIMENTS WITH PONIES.

Summary.—Seven ponies Nos. 260, 245, 263, 283, 285,
282 and 280 were treated with atoxyl and orpiment given
alternately with an interval of one day between each dose.

      * Journal of Tropical Veterinary Science, Vol. III, No. 4.