Medicine - Institutions > Army health reports and medical documents > Scientific memoirs by officers of the Medical and Sanitary Departments of the Government of India > Number 5 - Specificity of antivenomous sera > Specificity of antivenomous sera
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The following were the results obtained:—
| Animal. | Weight. | Amount of venom per kilo. | Amount of serum. | Result. |
| Rabbit 1 | 1,480 grammes | 0.5 milligramme | 1 c. c. | Found dead after 18 hours |
| ,, 2 | 1,680 „ | 0.5 „ | 2 c. c. | Ditto. |
| ,, 3 | 1,400 „ | 0.5 „ | 3 c. c. | Ditto. |
| ,, 4 | 1,510 „ | 0.5 „ | 4 c. c. | Ditto. |
| ,, 5 | 1,28o „ | 0.5 „ | Nil. | Ditto. |
| (Control.) |
B. In the second series of experiments a different sample of venom was used.
Of this sample it was found that the minimum amount which caused intravas-
cular thrombosis, when injected intravenously into a rabbit, was 0.2 milligramme
per kilo. A single experiment was made with this sample. The test dose used
was 0.6 milligramme per kilo., viz., three times the amount which could cause
intravascular thrombosis.
The technique was as follows:—5 c. c. of serum were injected into the
marginal vein of one ear: five minutes afterwards the test dose of venom
(0.1% solution) was injected into the marginal vein of the other ear.
The following was the result obtained:—
| Animal. | Weight. | Amount of venom per kilo. | Amount of serum. | Result. |
| Rabbit | 1,380 grammes | 0.6 milligramme | 5 c. c. | Died in 1½ minutes. |
From these series of observations it is therefore evident that the serum of a
horse immunised with the venom of Hoplocephalus curtus has no power to
neutralise the venom of Daboia Russellii.
Notes and references.
1. The information used in this paper concerning the classification of the
poisonous snakes was taken from ' Fauna of British India—Reptilia and
Batrachia' by Boulenger.
2. Calmette: ' Le venin des Serpents ': Paris, 1896. ' Notice sur le Sérum
Antivenimeux et sur le Traitement des Morsures de Serpents ': Lille, 1901.
3. ' Journal of Pathology and Bacteriology ': Edinburgh and London: 1902,
Vol. VIII, page 1.
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| Description | 61 volume new series covers bacteriological research work from 1902-1913 by Indian Medical Service staff. Laboratory experiments are recorded in detail. Many are accompanied by illustrations showing microscopic views and features of plant and animal matter. (Calcutta : Supt. of Govt. Print., India, 1885-1901.) |
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| Shelfmark | IP/QB.10 |
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| Description | 12 titles describe the health and sanitary conditions of the army in India. Lists British, European and Indian troops plus families of military personnel. 3 volumes of army regulations included. 73 volumes make up the Scientific Memoirs series, a journal by Indian Medical Service staff. |
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| Description | The Institutions collection consists of 106 volumes from British India, dating from the 1860's to the 1940's. Divided into reports on medical institutions, army health, and lock hospitals. Education of indigenous medical students and maintenance of troop health shown in annual reports and statistical tables. |
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| Description | The India Papers collection contains publications of the central (Imperial) Government and many Indian states. Most states came under British rule. Much of the collection dates from between the post-Mutiny re-organisation of the Indian Government and Indian Independence in 1947. Some items published in London by John Murray. |
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