62

Scientific Memoirs by

      On another occasion an acceleration of 55 sec. followed 4¼ hours after
taking 30 grains of gallic acid.

      Experiment at 10–30 A.M. Coagulation-time being 4 min. Tannic acid gr. 20 was taken
at 10–35 A.M.

      „ 1–30 P.M. „ „ was 3 „ 35 sec., an acceleration of 25
sec. after 3 hours.

      „ 4–30 „ „ „ „ 3 min., an acceleration of 1 min.
after 6 hours.

      This effect had quite passed off by noon the next day.

      Thus these drugs appear to have a distinct effect in accelerating coagula-
tion, which takes some hours to develope and passes off fairly quickly, They
are not so powerful as some of the other drugs tried. As was to be expected,
tannic acid acts somewhat more slowly than gallic acid.

Persalts of Iron.

      Although I cannot find any reference to the use of iron internally as a
hæmostatic except in cases of hæmatemesis, etc., where its action is a local one,
I was led to investigate its effect on intravascular coagulation by thinking of its
powerful local action in causing blood to clot, and obtained the following inter-
esting results:—

      Experiment at 10–30 A.M. My coagulation-time being 4 min. I took liquor ferri per-
chloridi 3ss. at 10–35
A.M.

      „ 1–30 P.M. „ „ was 4 „ 45 sec., a retardation of
45 sec. after 3 hours.

      „ 3–35 „ „ „ „ 2 „ 15 sec., an acceleration
of 1 min. 45 sec. after 5
hrs.

      „ 7–40 „ „ „ „ 2 „ 45 sec., an acceleration
of 1 min. 15 sec. after 9
hrs.

      The next day „ 10–30 A.M. „ „ „ 2 „ 15 sec., an acceleration
of 1 min. 45 sec., after
24 hrs.

      Again „ 10–30 „ „ „ being 3 „ I took liquor ferri per-
chloridi 3i at 10–45 A.M.

      „ 12–45 P.M. „ „ „ 2 „ 15 sec., an acceleration
of 45 sec. after 2 hours.

      „ 4–45 „ „ „ „ 2 „ an acceleration of 1
min. after 6 hours.

      „ 7–45 „ „ „ „ 1 „ 45 sec., an acceleration
of 1 min. 15 sec. after
9 hrs.