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would tend to spread outside the town of Cambay, for bugs are certainly just as
prevalent in the villages round as they are in the town itself. This argument,
however, would apply not only to the bug, but to every other blood-sucking
insect, especially to winged forms. My own view is, that in this particular
disease, we are dealing with a special parasite, whose life history, outside the
human body, is governed by very definite factors such as temperature, presence
or absence of the parasite in the circulating blood, and the bug in a suitable
stage.

       It is much to be regretted that such a careful observer as Dr. Row, still
endeavours to prove a hypothesis which has only a single fact to support it,
namely, the readiness with which the parasite can be scratched into the skin.
He ignores the overwhelming evidence in support of the parasite being trans-
mitted by a blood-sucking insect, and has therefore never studied the problem
from this point of view.

       From my own observations, and particularly the experiments carried out in
Cambay, I have no hesitation in saying that the house fly Musca nebulo and
Musca sp. play no part whatever in the transmission of the disease in Cambay,
and that Dr. Row's feeding experiments, conducted as they were in Bombay
with " trained" flies fed on richly infected material, are in no way comparable
to experiments carried out in the endemic area. Although I have failed up to
the present to actually transmit the parasite by the bed bug, I have brought
forward very strong evidence, by showing that the parasite only flagellates in
the bug below a certain temperature, and that this observation exactly coin-
cides with the geographical distribution of the disease in India. I hope in
time to be able to transmit the disease through the bug. I, however, wish it
to be clearly understood that the statements I have made above are at present
only applicable to Oriental Sore in Cambay. I am well aware that many
competent observers have stated that in other places where the disease is ex-
tremely prevalent, bugs, either Cimex rotundatus or Cimex lectularius, are
rare. I can express no opinion as to how the parasite is transmitted in these
places, but I fully realize that it may have more than one invertebrate host.
In Cambay, I have no doubt whatever that the bug Cimex rotundatus is the
only insect transmitter of the disease. My conclusions have not been arrived
at hastily, but are the result of a most careful and exhaustive study of the
disease and its probable transmitters.

       In conclusion would like to take this opportunity of thanking His High-
ness Mirza Jafir Ali Khan, Nawab of Cambay, and Mr. Madhavram Hari-
narayan, the Dewan of Cambay, for their kindness in making all arrangements
for my comfort during my stay in Cambay; also Mr. Dhanjiboy, the Chief

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