Medicine - Institutions > Army health reports and medical documents > Scientific memoirs by officers of the Medical and Sanitary Departments of the Government of India > Number 41 - Quinine and its salts > Front matter
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CONTENTS.
| PAGE. | ||||
| Introduction | . | . | . | 1 |
| Peculiarities of Quinine and its salts | . | . | . | 3 |
| Their solubility in water. | ||||
| Their deterioration (heat, light, moulds). | ||||
| Compatibility of Quinine salts with blood-serum | . | . | . | 6 |
| Solubility of Quinine alkaloid in blood-serum | . | . | . | 11 |
| Solubility of Quinine alkaloid in bile | . | . | . | 11 |
| Absorption of Quinine | . | . | . | 13 |
| Quinine elimination in the urine as a gauge of the amount of Quinine absorbed | . | . | . | 13 |
| Lethality as a measure of the amount of Quinine absorbed | . | . | . | 15 |
| A. Oral administration | . | . | . | 15 |
| Seat of absorption of Quinine | . | . | . | 15 |
| Factors influencing absorption from the gastro-intestinal tract | . | . | . | 18 |
(1)Food contents of the gastro-intestinal tract.
(2)Affections of the gastro-intestinal tract.
(3)Affections of the liver.
(4)The solubility of the Quinine salt employed.
The value of the lethality gauge as compared with Quinine elimination
in the urine as a measure of Quinine absorption.
(5)Carbon dioxide.
(6)Single large doses of Quinine as opposed to divided or " fractional " doses.
| The efficacy of Warburg's tincture explained | 22 |
| B. Subcutaneous (including intramuscular) administration | 22 |
| Miscibility of Quinine salt solutions with blood-serum: coagulum formation if the Quinine salt solution is concentrated |
23 |
| Precipitation of Quinine at the seat of injection | 24 |
| Variability in amount of Quinine eliminated in the urine. Effect of degree of concentra- tion of the Quinine injection on elimination |
25 |
| Quinine hydrochloride solutions containing urethane, antipyrine or sodium chloride | 26 |
| Facts, (a) experimental and (b) clinical, casting doubt upon the alleged therapeutic advan- tages of hypodermic injections of Quinine, as regards (1) amount of absorption and (2) promptness of effect |
26 |
| Minimum-lethal dose experiments on guinea-pigs to test the relative amount of absorption and promptness of action of Quinine after (1) oral and (2) subcutaneous administration |
28 |
| Reasons justifying the application of these results to man | 33 |
| Graphic representation (curves) of Quinine absorption after various methods of adminis- tration |
33 |
| Local and post-mortem changes in the guinea-pigs used in the minimum-lethal dose experi- ments |
34 |
| Quinine fundamentally unsuited for hypodermic injection | 35 |
| Dangers peculiar to Quinine when administered hypodermically | 35 |
| Intramuscular injections of Quinine | 38 |
| Intravenous injections of Quinine | 38 |
| Bacelli's solution of Quinine hydrochloride containing sodium chloride | 38 |
| Great dilution not only necessary in order to avoid the dangers noted after subcutaneous injections of Quinine but in itself beneficial in malignant malaria by attenuating the toxins and favouring their elimination |
33 |
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| Description | Their solubility and absorbability by A.C. MacGilchrist. |
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| Shelfmark | IP/QB.10 |
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| Description | 61 volume new series covers bacteriological research work from 1902-1913 by Indian Medical Service staff. Laboratory experiments are recorded in detail. Many are accompanied by illustrations showing microscopic views and features of plant and animal matter. (Calcutta : Supt. of Govt. Print., India, 1885-1901.) |
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| Description | 12 titles describe the health and sanitary conditions of the army in India. Lists British, European and Indian troops plus families of military personnel. 3 volumes of army regulations included. 73 volumes make up the Scientific Memoirs series, a journal by Indian Medical Service staff. |
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| Description | The Institutions collection consists of 106 volumes from British India, dating from the 1860's to the 1940's. Divided into reports on medical institutions, army health, and lock hospitals. Education of indigenous medical students and maintenance of troop health shown in annual reports and statistical tables. |
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| Description | The India Papers collection contains publications of the central (Imperial) Government and many Indian states. Most states came under British rule. Much of the collection dates from between the post-Mutiny re-organisation of the Indian Government and Indian Independence in 1947. Some items published in London by John Murray. |
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