Medicine - Institutions > Army health reports and medical documents > Scientific memoirs by officers of the Medical and Sanitary Departments of the Government of India > Number 21 - On the standardisation of anti-typhoid vaccine > On the standardisation of anti-typhoid vaccine
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contains about 21/3 times the amount of immunising element that vaccine I
contains.
| 19th May 1905. | Experiment III. | Serum of goat VII. |
| Dilution of vaccine. | Vaccine I. | Vaccine II. |
| Undiluted | Growth. | Growth. |
| 2-fold dilution | ,, | ,, |
| 3 | ,, | ,, |
| 4 | Sterile. | ,, |
| 5 | ,, | ,, |
| 6 | ,, | ,, |
| 7 | ,, | ,, |
| 8 | ,, | ,, |
| 9 | ,, | Sterile. |
| 10 | Growth. | ,, |
The growth in tube 10 of vaccine I was evidently an experimental error.
It is, therefore, left out of account. It is clear that the serum in this observation
was much less bactericidal than in either of the two experiments previously
detailed. We can calculate, in the same way as we have done before, that
vaccine II is 2 ½5 times stronger as regards its immunising power than vaccine I.
When we compare the results of these three observations made with
the same two vaccines but with three different sera on three different days, we
find that the relative strengths, as regards receptor content, were practically
constant, namely, (1) 1: 2.2, (2) 1: 2.3,and (3) 1: 2.4; the average of the three
observations being 1:2.3 We can, therefore, take it that vaccine I as regards
its immunising power is 2.3 times weaker than vaccine II and that the dose
of the former should be 2.3 times greater than in the case of vaccine II. If the
dose of vaccine II be I cc., then we would expect the same immunising effect
from 2.3 cc. of vaccine I.
In conclusion, we have now to show that this method of comparative stan-
dardisation is also applicable to filtrate vaccines. Wright and Windsor12 have
already demonstrated that the filtrate of a broth culture of bacillus typhosus
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| Description | 61 volume new series covers bacteriological research work from 1902-1913 by Indian Medical Service staff. Laboratory experiments are recorded in detail. Many are accompanied by illustrations showing microscopic views and features of plant and animal matter. (Calcutta : Supt. of Govt. Print., India, 1885-1901.) |
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| Shelfmark | IP/QB.10 |
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| Description | 12 titles describe the health and sanitary conditions of the army in India. Lists British, European and Indian troops plus families of military personnel. 3 volumes of army regulations included. 73 volumes make up the Scientific Memoirs series, a journal by Indian Medical Service staff. |
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| Description | The Institutions collection consists of 106 volumes from British India, dating from the 1860's to the 1940's. Divided into reports on medical institutions, army health, and lock hospitals. Education of indigenous medical students and maintenance of troop health shown in annual reports and statistical tables. |
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| Description | The India Papers collection contains publications of the central (Imperial) Government and many Indian states. Most states came under British rule. Much of the collection dates from between the post-Mutiny re-organisation of the Indian Government and Indian Independence in 1947. Some items published in London by John Murray. |
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