Medicine - Institutions > Army health reports and medical documents > Scientific memoirs by officers of the Medical and Sanitary Departments of the Government of India > Number 3 - Some observations on the poison of Russell's viper (Daboia russellii) > Some observations on the poison of Russell's viper (Daboia russellii)
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These observations are tabulated as follows:—
TABLE V.
Intravascular injection of incoagulable residue obtained by heating
a 1 per cent. solution of daboia venom.
Animal. | Weight in grammes. | Amount of residue in milligrammes per kilo. |
Result. | Post-mortem examination. |
Rabbit 9 | 1,750 | 4 | Death in 2 minutes. | Extensive intravascular clotting. |
Rabbit 10 | 1,745 | 1 | Death in 15 minutes. | Extensive intravascular clotting. |
Rabbit 11 | 1,750 | 0.75 | Death in 3½hours. | Clots in right ventricle. |
Rabbit 12 | 1,660 | 0.1 | No symptoms. |
(2) Effect of heating a solution of 0.1 per cent. strength as regards intra-
vascular clotting.
The material used for these experiments was the dried incoagulable residue,
obtained as detailed in experiment No. 2 above. It is necessary to recall the
method by which this was procured.
A solution of daboia venom of 0.1 per cent. strength was heated at 73º to
75º C. for half an hour. It was then filtered. The clear filtrate was evaporated
to dryness over a water bath at 60º C. The drying was completed over lime.
This dried residue was pounded, and the powder thoroughly desiccated over
sulphuric acid before it was weighed.
Rabbits were the animals employed. A 0.2 per cent. solution of this
powder was used for the injections, which were made intravenously. The
weights of venom refer to the dried residue. As no symptoms were observed in
any of the rabbits injected, it is unnecessary to detail this series of experiments,
which are tabulated as follows:—
TABLE VI.
Intravascular injection of incoagulable residue obtained by heating
a 0.1 per cent. solution of daboia venom.
Animal | Weight in grammes. | Amount of residue in milli- grammes per kilo. |
Result. |
Rabbit 13 | 1,550 | 1 | No symptoms. |
Rabbit 14 | 1,670 | 4 | No symptoms. |
Rabbit 15 | 1,570 | 8 | No symptoms. |
Rabbit 16 | 1,770 | 12 | No symptoms. |
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