On a remarkable bacteriolytic element found in tissues and secretions

Paper by Alexander Fleming about a natural antiseptic he calls 'lysozyme'.

Date: Published in 1922.
Publication: Proceedings of the Royal Society of London, Series B, Volume 93, Pages 306-317, Plates.


In this 'communication', Alexander Fleming draws attention to a substance found in tissues and secretions that can rapidly dissolve bacteria.

He calls the element 'lysozyme', and reveals how he discovered it in the nasal secretions from a patient. He then describes this 'microbe' and how the experiments on it at St Mary's Hospital, London, were carried out.

The paper was published in May 1922, with three illustrations of culture plates. Sir Almroth Wright 'communicated' Fleming's paper, and the Royal Society of London received it on 13 February 1922.